Pathogenesis

Researchers find link between intestinal bacteria and auto immune disease

Translocation of Enterococcus gallinarum, a gut bacterium, drives a mouse model of systemic lupus erythematosus, according to a recent study.
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Platelets Offer Promising Treatment Target

Platelets and their microparticles play important roles in the pathogenesis of lupus and therefore represent promising clinical targets.

Platelet system activation not only denotes disease activity but also induces immune dysregulation and tissue damage in systemic lupus erythematosus (SLE). Understanding the intricate roles platelets play in inflammation and autoimmunity could reveal “new potent therapeutic pathways,” Marc Scherlinger, MD, of Centre Hospitalier Universitaire in Bordeaux, France, and his associates (Autoimmun Rev. 2018;17:625-35).

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